Blood pressure management A crucial goal for the prevention of CKD progression, cardiovascular disease (CVD) and heart failure is managing blood pressure
Medical conditions affecting absorption warrant particular attention : Pernicious anaemia : an autoimmune condition destroying gastric parietal cells, requiring lifelong B12 injections Gastrointestinal surgery : particularly gastric bypass, gastrectomy, or terminal ileum resection Inflammatory bowel disease : Crohn's disease affecting the terminal ileum impairs absorption Coeliac disease : untreated disease damages the small intestine, reducing B12 uptake Medication use : long-term metformin therapy (MHRA safety alert) or nitrous oxide exposure Symptoms suggesting possible B12 deficiency include : persistent fatigue, weakness, paraesthesia (pins and needles) in hands or feet, glossitis (sore, red tongue), mood changes, memory problems, or unexplained anaemia
For severe cases, glutathione is given intravenously as 50-100mg per kg body weight
[1] However, Mounjaro is the brand-name version of tirzepatide FDA approved for type 2 diabetes, not weight loss
After 18 months, the study participants showed not only improved metabolic markers but also better memory and cognitive function
Gogvadze V, Orrenius S, Zhivotovsky B
