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Another GoF variant, A316T, shows a 2-fold increase in cAMP accumulation ( 2+ mobilization (which is essential for insulin secretion)

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Retrieved from Accessed 17 Aug 2024 Collins L, Costello RA (2023) Glucagon-like peptide-1 receptor agonists

Dou, W.-F

This represents a significant jump to approximately 0.9 mg, crossing into the range where meaningful metabolic effects begin