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P., Shah, R., & McCarty, T

10.1126/science.1128294 Science 140 PapadopoulosV.MillerW

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When a conflict between the above reviewers arose in the first screening, then the study was included for further analysis anyhow

Its deficiency in the human diet results in disturbances in many important biochemical and metabolic processes, such as an impaired glucose metabolism, disrupted bioenergetic processes, mitochondrial dysfunction, lactic acidosis (the consequence of pyruvate dehydrogenase [PDH] dysfunction in mitochondria), insufficient DNA synthesis due to low transketolase activity and ribose-5-phosphate synthesis in the pentose phosphate pathway and impaired neurotransmitter synthesis

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