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Taking a multivitamin during the initial titration phase of GLP-1 therapy may compound nausea

Previous studies have shown that the sustained loss of GABAergic interneurons induced by ketamine was linked to an upregulation of the enzyme responsible for the synthesis of superoxide radicals, which are responsible for stereotypical behaviors and depression (21, 85)

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Understanding your genetic predispositions can help frame a more informed discussion with your provider about whether the additive benefit of combination therapy addresses your specific metabolic phenotype, or whether monotherapy or alternative agents might be more efficient for your genetics and lifestyle

This is why tirzepatide is taken once a week instead of every day