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The dose-dependent increase in GI adverse events is consistent with GLP-1 receptor activation patterns seen with semaglutide and tirzepatide at comparable therapeutic levels

Future research should prioritize understanding the mechanisms underlying host-microbiota interactions, improving the bioavailability of key dietary components, and evaluating the long-term effects of dietary interventions on microbial ecology

Switch over from one food to another should be done gradually by mixing small amounts of both foods during a period ofone week

FGF21, a protein implicated in fat and sugar utilization, decreased at higher doses, which may indicate enhanced metabolism