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(2012) 10(7):e1001361

Customized compounded medications are prepared in various dosage forms and strengths pursuant to valid prescriptions when commercially available options are not clinically appropriate

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A recent study employed single-molecule array (Simoa), an ultra-sensitive technology, to quantitate very low concentrations (picomolar to femtomolar) of -synuclein protofibrils (PFs) in CSF of PD patients and observed an increased concentration of -synuclein PFs in PD patients (von Euler Chelpin et al., 2020)