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Overview of main clinical studies for MASLD/MASH with GLP-1 receptor agonists and dual or triple agonists targeting glucagon/GIP/GLP-1 receptors Liraglutide Liraglutide, a once-daily GLP-1 receptor agonist with authorized indications for type 2 diabetes and obesity, was evaluated in the LEAN trial (NCT01237119), a phase 2 randomized controlled study enrolling 52 adults with biopsy-proven MASH [22]

The interplay among oxidative stress, brain insulin resistance and AMPK dysfunction contribute to neurodegeneration in type 2 diabetes and Alzheimer disease

In a clinical study involving patients with early threatened miscarriage, treatment with a modified Shoutai Pill significantly upregulated mRNA expression of GPX4 and SLC7A11 and downregulated transferrin receptor 1 expression

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hence, dual activation of GIP and GLP-1 receptors by TRZ effectively reduces body weight