A note on GLP-1 agonists for weight loss Though GLP-1 agonists can be beneficial for weight loss, its important to keep in mind that there is limited research on the long-term effects of these medications
Efficacy and safety of dulaglutide 3.0 mg and 4.5 mg versus dulaglutide 1.5 mg in metformin-treated patients with type 2 diabetes in a randomized controlled trial (AWARD-11)
Expert Opin Pharmacother 26(1):3149 [DOI] [PubMed] [Google Scholar] 23.Jastreboff AM, Aronne LJ, Ahmad NN et al (2022) Tirzepatide Once Weekly for the Treatment of Obesity
Intestinal proglucagon cleaves (breaks up) into several different molecules: GLP-1 GLP-2 GRPP Oxyntomodulin The enzyme PCSK1 converts proglucagon to GLP-1 in the central nervous system
Moreover, there was no difference in weight changes between exenatide and abiglutide, and both were shown to exhibit remarkable weight loss effects (174)
Cascieri MA, Koch GE, Ber E et al (1999) Characterization of a novel, non-peptidyl antagonist of the human glucagon receptor
