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In conclusion, this real-world study emulating a target clinical trial shows that among a national cohort of patients enrolled at the VHA with moderate to advanced CKD, use of GLP1-RA was associated with lower annual rate of acute healthcare utilization, lower all-cause mortality, and lower kidney events as compared to treatment with DPP4i

Patient education and training for safe self-administration are critical, and gaps in support may impact adherence and outcomes

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