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PARP-1, the enzyme the body relies on to repair damaged DNA, can no longer work at full capacity

Developing cell-type-specific SIRT1 regulatorsfor example, hepatocyte-targeted molecules using GalNAc ligands or KC-specific nanoparticlesmay allow targeted activation, while selective inhibition in cells such as activated HSCs could also be explored

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Glutamine is an important nutrient for supporting normal gut metabolism and intestinal function, particularly in tissues with high nutrient demand

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