Consistent with this TFEB-dependent remodeling of the endolysosomal system, zinc also induces the expression of lysosomal proteases, including cathepsins B and D, thereby enhancing lysosomal proteolytic capacity 103
These mutations can alter the enzymes effectiveness, potentially leading to health issues, earlier for some and over time for others
Important caution: Given the dual role of glutathione in cancer biology, glutathione or NAC supplementation should NOT be taken during active cancer treatment without oncologist approval, as it could theoretically protect tumor cells from therapy [2][5]
Moving from 0.5% to 1%, or from 1% to 2%, represents appropriate steps
It is also not known whether hydroxocobalamin can cause fetal harm when administered to a pregnant woman or can affect reproduction capacity
Other Digestive enzyme supplements: If your dogs B12 deficiency is due to a digestive issue like EPI (see above section, What can cause B12 deficiency in dogs?), then adding a digestive enzyme supplement can help them break down food better and may improve the absorption of B12 and other nutrients
