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This breakdown or dyshomeostasis of biometals whereby antioxidant protection is overwhelmed in favor of elevated concentration of metals leads to a state of neurotoxicity with damaging interaction to proteins, lipid peroxidation, and DNA, all evidence of increased oxidative stress in the AD affected brain (Jomova et al., 2010
L-Carnitine is a chemical organic compound from the group of amino acids that naturally occur in our body
[DOI] [PMC free article] [PubMed] [Google Scholar] 186
This leads to reduce secretion of incretin hormones, glucose-dependent insulinotropic polypeptide and glucagon-like peptide 1, and subsequently leads to PPDM-A[24]
Studies suggest that glutathione levels naturally decrease with age, along with exposure to stress, UV radiation, tobacco, alcohol, and environmental toxins like pollution
A particular topic is its role in mediating Robert gastric cytoprotection and endothelial maintenance (Sikiric et al., 2010
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