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[PMC free article: PMC6417689] [PubMed: 30325658] 76

NICE Guideline NG28

That is why it is important to consider what treatments are the best fit for your goals

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Patients with Mitochondrial Disease:There is an increased risk of valproate-induced acute liver failure and resultant deaths in patients with hereditary neurometabolic syndromes caused by DNA mutations of the mitochondrial DNA Polymerase (POLG) gene (e.g., Alpers-Huttenlocher Syndrome)