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Discontinue Byetta if pancreatitis is suspected Notes: The discovery of DPP-IV-resitant GLP-1 analogs was pursued in parallel with the discovery of DPP-IV inhibitors

The American Diabetes Association (ADA) Standards of Care emphasize that diabetes is a progressive condition requiring ongoing pharmacological management in most patients, and discontinuing effective therapy typically results in deterioration of glycemic control

The risk is considered small for semaglutide and tirzepatide, but it exists

On days when appetite suppression is severe, use calorie-dense but nutrient-rich foods to meet minimums

The responsible clinical approach is to titrate slowly, evaluate response at each stage with monitoring, and stop increasing when results are adequate rather than when the theoretical maximum has been reached

For many people, this is a small price to pay for avoiding needles entirely