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One of the cleaner ones, a 24-week randomized study of 279 mild-to-moderate Alzheimers patients, tested three doses against placebo and found a result no marketer would have designed: the lowest dose, 10 mL a day, beat placebo on both a cognitive scale and a global clinical rating, while the higher 30 and 60 mL doses improved the global rating but not cognition (Alvarez et al., Eur J Neurol 2006, randomized controlled trial)

PE-22-28 has a cleaner evidence record and a well-characterized ion channel target, but its cognitive effects are less directly studied than its antidepressant properties

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Figure 2 2.1 Warburg effect and glycolysis in cancer Glucose metabolism is a central pathway for cellular energy production and biosynthesis