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(1) Dietary pattern adaptation Western populations (Europeans, Australians): the Mediterranean diet (rich in omega-3 and olive oil) reduces depression risk, as their gut microbiota (high Faecalibacterium abundance) efficiently metabolizes omega-3 into anti-inflammatory resolvins (86, 87, 331)

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This finding suggests that liraglutide mainly produces prophylactic analgesic effects

In some embodiments, the otic formulation or composition comprises between about 0.001% to about 15% by weight of the therapeutic agent, or pharmaceutically acceptable prodrug or salt thereof