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Concluding remarks The mechanisms of APAP-induced liver injury are highly complex and many intracellular and extracellular events are involved in this pathophysiological process, including metabolism of APAP, mitochondrial oxidative stress, ER stress, autophagy, sterile inflammation, microcirculatory dysfunction and liver regeneration

227 The probiotics Bifidobacterium BGN4 and Lactobacillus fermentum HFY06 can also mediate the differentiation of T cells, inhibit the expression of IL-1 and COX2, promote the expression of the anti-inflammatory cytokine IL-10, enhance epithelial barrier function and reduce damage to the intestinal barrier by inhibiting the NF-B signaling pathway

Ardestani, A

These changes are usually reversible with adequate hydration, but they can look alarming on paper

probiotics add new, good bacterial strains to the mix

Statements Author contributions YT: Conceptualization, Supervision, Validation, Writing original draft, Writing review & editing