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Upon infection with SARS-CoV-2 and when the virus has successfully overcome the first line of defense, virus antigens that are known as pathogen-associated molecular patterns (PAMPs) activate the synthesis of antimicrobial substances in serum, such as interferons (IFN) and complement proteins

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Immunoprecipitates and input samples were then subjected to immunoblotting or mass spectrometry analysis

Together, these studies highlight that the outcome of efferocytosis of infected apoptotic cells is strongly influenced by the nature of the pathogen cargo as well as the identity of the phagocyte, underscoring the context-dependent plasticity of efferocytic responses [55]

Therefore, the above results suggested that ATF4 could suppress HuOCSC ferroptosis