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The system was heated to a final temperature of 300 K in three steps: 0 to 100 K for 10 ps (NVT), 100 to 200 K for 20 ps, and 200 to 300 K for another 20 ps, all under NPT conditions (1 atm pressure)

3.1 VDRs and distribution Active form of vitamin D, 1,25-dihydroxyvitamin D (calcitriol), can cross the bloodbrain barrier and interact with vitamin D receptors (VDRs), which are found in brain areas involved in cognition, including the hippocampus, prefrontal cortex, amygdala, and thalamus (68)

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