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Inside the cell, the -glutamyl amino acid is hydrolyzed by -glutamyl cyclo-transferase and converted into oxoproline and a free amino acid

Furthermore, unbalanced microbiota may worsen systemic diseases such as diabetes, further complicating healing

Kurian AG, Singh RK, Sagar V, Lee J-H, Kim H-W

It can be highly activated by various stress stimuli, where it is required for the re-folding of damaged and unfolded proteins generated under stress 43

They will blend and absorb into skin upon application

Hydration & barrier function is important in the treatment of melasma as topical pigment correctors are frequently irritating