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It is found in almost every cell in the body, where it acts as a primary shield against oxidative stress

There was no plateau in weight loss at 46 weeks with the potential of further weight loss over a longer time period

The pathogenesis involves oxidative stress, inflammation and impaired Ca2+ handling as well as alterations in substrate metabolism/utilization, insulin signaling, gene regulation, mitochondrial dysfunction, ERS, neurohumoral activation and cardiomyocyte death (114)

Lipid exchange at ER-mitochondria contact sites: a puzzle falling into place with quite a few pieces missing

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doi: 10.1016/j.ghir.2009.03.001 123 FalutzJPotvinDMamputuJCAssaadHZoltowskaMMichaudSEet al