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We next assessed the specific DPP-4 + cell types essential for transducing the inhibitory actions of DPP4i in control of lipid tolerance

In these studies, participants using a 2.4 mg weekly dose of semaglutide, alongside lifestyle interventions, lost an average of about 15% of their initial body weight over 68 weeks

It is not inevitable and often resolves with dose stabilization, behavioral support, or adjustment

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Its also approved for children aged 12 and older with obesity and a weight of over 60 kg (~132 lb)