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As the field develops, direct measurement of circulating MOTS-c may become a useful biomarker for guiding dose adjustments, similar to how IGF-1 is used to monitor growth hormone or testosterone levels guide TRT dosing

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Notably, the study demonstrates that co-culture with synovial organoids stabilizes chondrocyte morphology and supports more cartilage-like phenotypes

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Proper reconstitution of the lyophilized peptide with bacteriostatic water is the first critical step

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