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The formation of metal complexes can improve the solubility, bioavailability, and cellular uptake of curcumin, enhancing its pharmacological, chemopreventive, and therapeutic activities compared to the free molecule and its uncoordinated derivatives

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The findings revealed that irregular activation of HGF/c-MET enhanced TGF- release from cancer cells, reduced CTL penetration at the tumor site, and eventually caused immune evasion