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The brief duration of action means that endogenous GLP-1 functions as a meal-related signal rather than providing sustained metabolic control

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In particular, FOXO1 regulates cell cycle progression, apoptosis, and angiogenesis 144,145 , and promoted both in vivo and in vitro wound healing by preventing oxidative stress in keratinocytes via the upregulation of GPX-2 and GADD45 thus maintaining TGF-1 mediated migration and apoptosis inhibition 146

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(2021) 184:413753.e14

Mechanisms of Insulin Resistance, Mitochondrial Dysfunction and the Action of the Ketogenic Diet in Bipolar Disorder