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Additionally, they attenuate mammalian target of rapamycin (mTOR) activity through the inhibition of AKT-mediated prolin-rich akt substrate (PRAS40) phosphorylation, indicating that GLP-1R agonists (GLP-1RAs) help to control inflammation and immune responses in hCASMCs, improve vascular health, and may positively impact the treatment of atherosclerosis by modulating the AKT and mTOR signaling pathways (Li BY

LigPlot+: multiple ligand-protein interaction diagrams for drug discovery

Every time we exercise, we burn calories and therefore glucose

A new review explores how GLP-1 receptor agonists may blunt alcohol and drug reward signals, opening a promising but still unproven path toward repurposed treatments for addiction

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Increase in pancreatic proinsulin and preservation of -cell mass in autoantibody-positive donors prior to type 1 diabetes onset