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These consist of: Pernicious anaemia - In the UK, pernicious anaemia is the most common trigger for vitamin B12 deficiency

Being a vegetarian or vegan : This group consumes less foods that are naturally high in vitamin B12, such as beef and poultry (and sometimes dairy and fish too), which means their intake of vitamin B12 is lower whether their absorption is adequate or not

Potency depends on proper storage and handling

The vitamin is a cofactor for methionine synthase, which catalyzes the conversion of homocysteine to methioninerequired for the formation of S-adenosylmethionine, a universal methyl donor for almost 100 substrates, including DNA, RNA, hormones, proteins, and lipids

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