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Datos toxicolgicos preclnicos: Los estudios de toxicidad aguda y subaguda en la rata no han evidenciado mortalidad ni toxicidad orgnica significativa, incluso a dosis ampliamente superiores a las dosis teraputicas (hasta 100 veces la dosis eficaz)

Significant improvements in HbA1c (glycated haemoglobin, reflecting average blood glucose over 23 months) are generally observed after 812 weeks of treatment

Therefore, maintaining adequate levels of this vitamin is essential for overall health and well-being

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Myocardial infarction and cerebrovascular infarction rates were not significantly different between groups