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The KEAP1-NFE2L2 pathway, with the most enriched genes, was selected for further study

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(3) ROS induces DNA oxidative damage (such as formation of 8-OHdG) and lipid peroxidation (MDA increase), triggering chondrocyte apoptosis through Bax/Bcl-2 imbalance and activation of caspase-3

Principle of Neural Science (McGraw-Hill, New York, 2000) Kuhn, H