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This is because Gpx4 is the only GPx enzyme that breaks down phospholipid hydroperoxides

Hypervitaminosis B12 in commercial broiler chickens

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Low levels of glutathione have been associated with various health conditions, including chronic diseases such as cardiovascular disease and neurodegenerative disorders

Chronic systemic inflammation is also associated with elevated lipolysis in white adipose tissue and lipogenesis in nonadipose tissues, causing ectopic fat deposition in nonadipose tissues and imbalance in free fatty acid homeostasis and increased risk of IR [63]