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While this effect appears to be related to the magnitude and rapidity of glucose lowering rather than a direct effect of the medication itself, patients with a history of diabetic retinopathy should undergo careful ophthalmologic evaluation before and during treatment, and the potential risks should be weighed against the expected benefits of improved glycemic control

These results suggest that the growth inhibitor of the delta cells exerts a sustained inhibitory effect on the secretion of insulin and glucagon, and that it may promote the responses of the islets to activation by cholinergic stimuli

Retatrutide may, in time, receive regulatory approval and become a valuable addition to the weight management toolkit

Lancet 405 , 15801593 (2025)

Kazda, C

Drawing "20 units" on a U-40 syringe delivers 0.5 mL, not 0.2 mL, a 2.5x overdose