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through CoA, vitamin B participates in the synthesis of neurotransmitters, steroid hormones, and other key cellular components

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This is one of the many reasons I often recommend that thyroid patients just supplement with B12 in almost every case

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Secondary folic acid deficiency The molecular basis of the inherited folate absorption disorder is a mutation in the SLC46A1 gene, which encodes the proton-coupled folate transporter (PCFT)