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This study can be a node for developing more mature and controlled studies to evaluate the effect of vitamin B12 as a safe and potentially important moderator of nociplastic pain and psychological illness in FM

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It involves specific enzymes and nutrients, particularly vitamin B2, B6, B12 and B9, and serves several functions such as gene regulation (epigenetics), biotransformation, myelination, synthesis of neurotransmitters, as well as DNA and RNA synthesis