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Vildagliptin in addition to metformin improves retinal blood flow and erythrocyte deformability in patients with type 2 diabetes mellitusresults from an exploratory study

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The catalytic activity of the molecule was suggested to be, at least partially, involved (since insulin signaling was improved following inclusion of a DPP-4 inhibitor), but the DPP-4 substrate(s) mediating the effect were not identified

However, some sports medicine research suggests that taking it alongside a small amount of complex carbohydrates may stimulate a mild insulin release, which has been shown to further drive carnitine uptake directly into the skeletal muscle tissues, enhancing its recovery benefits

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[DOI] [PMC free article] [PubMed] 44.Filippatos TD, Panagiotopoulou TV, Elisaf MS