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The current research on this topic is quite limited
Under hypoxia or mitochondrial dysfunction, -KG can be converted to citrate by Isocitrate dehydrogenase (IDH 2) catalyzed carboxylation reaction, which is used for the synthesis of amino acids and fatty acids and the production of reducing agent NADPH
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In: J Andrology
It also causes widespread oxidative damage to neuronal macromolecules, significantly contributing to the characteristic selective striatal neuronal loss in HD
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If Im treating a diabetic patient on metformin who wants to try semaglutide, I usually add it and continue metformin until I see how their glucose levels respond, says Jennifer Brown, DO, ABOM, ABFM, a board-certified obesity and family medicine specialist at Maxwelton Health Center in West Virginia
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