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The 14-week, double-blind, 25 participant study found that "there was a significant degree of improvement in fines lines ", though the participants did not report a significant difference in the quality of their skin

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It does this by reducing the elevated oxidative stress and addressing the low glutathione levels experienced by those suffering from Alzheimers disease (6)

ROS can regulate DNA damage and cell signaling pathways, leading to an imbalance of skin antioxidants, thus accelerating skin photodamage [25]

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Conclusion: Although GHK-Cu and Pal-GHK are effective and relatively skin permeable, their permeability could be successfully increased using permeation enhancement methodologies