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The small tetrapeptide size (~390 Da) makes Epithalon subject to rapid enzymatic cleavage and renal clearance

Following its dissociation from the a 2 -macroglobulin, the peptide is proteolytically cleaved to generate a C-terminal pentapeptide, which activates an intracellular Gi-protein-MAP kinase signalling pathway [232, 233]

Experimental models indicate that the peptide may contribute to the restoration of tendons and ligaments by improving local vascular responses at injury sites

Glutathione: an old and small molecule with great functions and new applications in the brain and in Alzheimers disease

[DOI] [Google Scholar] 162.Gould S., Scott R.C