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This hypothesized VEGF/VEGFR interaction may activate a complex intracellular signaling cascade, which may involve multiple proteins such as phospholipase C, protein kinase C, and the mitogen-activated protein kinases

The clean profile comes from animals and cells

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Rajput I, Prasad KR, Bellamy MC, Davies M, Attia MS, Lodge JP

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The reason has been ascribed to loss of proteasome activity over time