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Zepbound users lost up to 22.5% of body weight in clinical trials, while Ozempic users lost an average of about 14.9% Zepbound works on two receptors (GIP and GLP-1), giving it stronger effects on weight and blood sugar Both medications share similar side effects, mostly stomach-related symptoms Cost and insurance coverage vary widely, making accessibility a major factor in choosing between them Long-term use is required for both drugs to maintain results Choosing between Zepbound and Ozempic is a decision millions of people face when starting their weight loss journey