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the original rodent study used 5 mg/kg, which when scaled allometrically to human equivalents suggests doses in the 5-10 mg range for a 70 kg adult, though allometric scaling from mice to humans is an imprecise science

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The trial included over 3,400 people with a BMI of 30 or above (or 27+ with at least one weight-related health condition) and without type 2 diabetes

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Second reaction: Holo-AASS converts saccharopine into -aminoadipate semialdehyde using H 2 O and NAD + , releasing NADH, H + , and glutamate