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confirmed that intranasal Semax application induces rapid, gene-specific and region-specific neurotrophin mRNA changes across the rat brain including BDNF upregulation in the hippocampus, brainstem, and cerebellum establishing a comprehensive transcriptional neurotrophin signature that goes beyond a single brain region or gene target

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NADP(H) 4 , linking the two redox systems

tested the effect of acute or extended incubation with GLP-1 and GIP, alone or in combination, and they reported that treatment with GLP-1 and GIP significantly enhanced glucose-stimulated insulin release but had no apparent synergistic effect in diabetic human islets (15)

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Proper screening and clinical supervision are essential