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Experts increasingly advocate aligning safety expectations for high-risk probiotic products (e.g., LBPs) with those applied to other complex biologicals, including systematic genomic characterization, standardized adverse-event reporting, and structured post-market surveillance, while avoiding unnecessarily stricter requirements than for comparable biologic therapies (525)
Free Radic Biol Med 2004;36:145-51
These imbalances are associated with reduced GSH levels, a lower overall antioxidant capacity and the activation of nuclear factor kappa B (NF-B), a transcriptional factor for inflammatory pathways (Naik et al., 2011)
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2006), therefore, the activation of PI3K/AKT/CREB/BDNF pathway is highlighted as a striking therapeutic approach for amelioration of ADHD