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10.1167/iovs.62.3.38 190 UzunogluS.KaragolH.OzpuyanF.CosarR.CicinI.YurutcalogluV.et al (2011)

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Clinical studies have shown after 56 days of application, skin elasticity improved by 11.1%, skin firmness by 1.5%, and face sagging by 16%. Specifically, the jawline contour showed a 1% increase in firmness and 11% improvement in elasticity, demonstrating its capacity to enhance skin structure and reduce the appearance of aging

Alteration of ATG genes have been found in diabetic mouse models, including the deletion of Atg5 and Atg7 in PTECs, which is associated with the accumulation of damaged mitochondria, tubular cell apoptosis and renal fibrosis (108)

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Inhibition of dipeptidyl peptidase-4 augments insulin secretion in response to exogenously administered glucagon-like peptide-1, glucose-dependent insulinotropic polypeptide, pituitary adenylate cyclase-activating polypeptide, and gastrin-releasing peptide in mice