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High histamine levels can stimulate insulin secretion from the pancreas, potentially causing blood glucose fluctuations and hypoglycaemia
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El estudio de Clark y cols
Briefly, a closed testing procedure that operated based on an overall significance level of alpha = 0.05 was allocated to the initial test, which was either a test of non-inferiority for SEM 14 mg compared to active comparators (empagliflozin in PIONEER 2 and sitagliptin in PIONEER 3) or a test of superiority for SEM 14 mg compared to placebo (PIONEER 1, 4, and 8)