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Ethics declarations Ethics approval and consent to participate The Ethics Committee of The Third Hospital of Qinhuangdao approved all experimental protocols

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(28) The crude incidence rates of amputation were 6.1 per 10,000 person-years for GLP-1s, 1.5 for SGLT-2 inhibitors, 4.6 for DPP4-Is, and 1.9 for other agents