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GLP-1, which is often low or insufficient in diabetes patients, regulates blood glucose levels by stimulating insulin secretion and inhibiting glucagon release, says Mir Ali, MD, a bariatric surgeon and medical director of MemorialCare Surgical Weight Loss Center at Orange Coast Medical Center in Fountain Valley, California

In the semaglutide group, the researchers saw significant changes between baseline and 32 weeks for high-sensitivity C-reactive protein (a 40% decrease), interleukin-6 (a 19% decrease) and soluble CD163, a marker of macrophage activation (a 12% decrease)

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2 The rest stayed on lower doses, usually because of side effects

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