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3d) in the livers from HFD-fed mice was significantly lower than that in control livers

The per-mg savings flatten above 100mg, so there's little reason to chase 200mg unless you're mixing your own topical solution

H., de Andrade P., Wu Y., Spring D

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The compounds don't compete for binding sites, don't share metabolic pathways during clearance, and don't modulate the same downstream signaling cascades

Di Stefano, M