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652: 1178 Minkler PE, Ingalls ST, Hoppel CL

Recently acquired Metsera is making a GLP-1 drug candidate that is long acting and oral, which could make a huge difference, Bourla said

This releases the Notch intracellular domain (NICD), allowing its translocation to the nucleus where it promotes expression of the lst-1 and sygl-1 stemness genes, and acts as the niche signal allowing GSCs to proliferate 15,16,17,18

This is why some individuals struggle with weight loss despite significant efforttheir endogenous GLP-1 system is simply underperforming

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