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NAD+ levels decline approximately 50% between ages 40 and 60 (Massudi et al., 2012), driving interest in direct supplementation to restore youthful concentrations

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A 2024 case series in Journal of Clinical Endocrinology reported that patients receiving combination therapy showed 18% greater fat mass reduction compared to GLP-1 monotherapy, with improved energy scores on validated fatigue assessments (Morrison et al., 2024)

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