Samita Garg, MD, associate professor of medicine at Cleveland Clinic Lerner College of Case Western Reserve University, and director of multidisciplinary gastroenterology endocrine GLP clinic in the department of gastroenterology, hepatology and nutrition at the Digestive Disease Institute, Cleveland Clinic Foundation, said the prevalence of overweight and obesity has been increasing among people with type 1 diabetes in recent years
Clinical parameters of each group of the DKD rats were shown in Table 1
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Notably, propionate has been shown to directly stimulate GLP-1 release in controlled experimental settings, creating a positive feedback loop whereby GLP-1 RA-induced microbial changes lead to more SCFA production, which in turn further amplifies endogenous GLP-1 and PYY secretion (67)
However, the major (~ 7080%) cause of death in T2DM patients is related to cardiovascular disease (35,36)
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